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Updated: May 11, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
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模块化光开关分子用于活细胞中蛋白质功能的化学光遗传控制

Jun Zhang1,2, Laura K Herzog1,2, Dale P Corkery1,2

  • 1SciLifeLab, Department of Chemistry, Umeå University, 90187, Umeå, Sweden.

Angewandte Chemie (International ed. in English)
|January 8, 2025
PubMed
概括

研究人员开发了可光开关的分子剂 (sMGs),用于精确的,光控制的细胞功能的操纵. 这种多功能化学光遗传系统允许可逆切换蛋白质活性,定位和水平,具有高的时空精度.

关键词:
化学诱导的二分化.化学光遗传学 化学光遗传学分子粘合剂是一种分子粘合剂.照片交换机 照片交换机蛋白质降解 蛋白质降解

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Channel Rhodopsins01:11

Channel Rhodopsins

Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...