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Updated: Jun 3, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

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Published on: October 26, 2015

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针对非激酶和激酶的细胞活性,氨酸向的不可逆转共价抑制剂

Peng Chen1,2, Lu Wang3, Xuan Wang1,4

  • 1Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore.

Angewandte Chemie (International ed. in English)
|January 8, 2025
PubMed
概括

研究人员开发了一种针对向共价抑制剂 (TCI) 的基于糖的新策略,该策略可以选择性地向Mcl-1和AURKA等蛋白质中的氨酸残留物. 这种方法为药物发现和针对困难蛋白质提供了新的工具.

关键词:
基因酶激酶的使用方法在阿根廷,阿根廷人.作为一种共价抑制剂.这就是glyoxalxal.药物前体是药物前体.

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