在阿萨姆的茶种群中慢性肺性阿斯伯吉洛症
Aishwarya Selvasekhar1, Reema Nath1, Gourangie Gogoi2
1Department of Microbiology, Assam Medical College & Hospital, Dibrugarh, Assam, India.
PLoS neglected tropical diseases
|January 8, 2025
概括
这项研究发现,印度阿萨姆州的茶园工人患有慢性肺性阿斯伯吉洛症 (CPA) 的高患病率. Aspergillus IgG抗体测试对于诊断CPA至关重要,特别是在肺结核后患有呼吸道症状的患者中.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 慢性肺性阿斯伯吉洛症 (CPA) 是由阿斯伯吉洛菌种引起的肺部疾病,通常呈现出腔腔病变.
- 印度阿萨姆邦的茶园工人患结核病的发病率很高,是呼吸系统健康研究的重点.
- 这项研究调查了Dibrugarh茶园社区慢性呼吸系统症状的个体中Aspergillus IgG抗体和CPA的患病率.
研究的目的:
- 为了确定患有慢性呼吸系统症状的个体中阿斯伯吉卢斯IgG抗体的流行率.
- 为了确定茶园人口中慢性肺阿斯伯吉洛症 (CPA) 的患病率.
- 评估结核病史与阿斯伯吉勒斯病毒阳性之间的关联.
主要方法:
- 在茶园医院和转诊中心进行了一年的横截面研究.
- 从128名患有慢性呼吸道症状的患者的血清样本中,使用Immunocap Phadia 200测试了Aspergillus fumigatus特异性IgG抗体.
- CPA诊断是基于临床,放射学和血清学标准.
主要成果:
- 总体上阿斯伯吉勒斯的血清阳性为32.0% (41/128).
- 显著的症状包括血和疲劳 (p<0.01).
- 在有肺结核病史的患者 (38.1%),特别是在结核病后组 (48.9%) 中,阿斯伯吉勒斯IgG抗体显著更高. 已证明的CPA被诊断在17.1%的患者中,可能的CPA在14.8%的患者中.
结论:
- 在受研究的人群中检测到CPA的高患病率 (每10万人中有60人).
- 对Aspergillus特定的IgG抗体测试对于CPA诊断至关重要,特别是在结核病后的患者中,这些患者呈现慢性呼吸道症状.
- 在高风险群体中早期检测阿斯伯吉勒斯血清阳性可以改善CPA管理.
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