替代疗法与脊椎骨折的发病率增加有关:一个匹配的回顾分析
Manjot Singh1, Mohammad Daher, Bassel G Diebo
1From the Warren Alpert Medical School, Brown University, Providence, RI (Singh and Daher), and the Department of Orthopedics, Brown University, Providence, RI (Dr. Diebo, Dr. Daniels, and Dr. Arcand).
概括
替代疗法 (TRT) 与男性和女性脊椎骨折的风险更高有关. 对于接受TRT的患者,建议对骨折风险进行查.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 整形外科 整形外科 整形外科
背景情况:
- 替代疗法 (TRT) 与脊椎骨折风险之间的关系尚未得到充分证实.
- 了解这种关联对于患者安全和治疗指南至关重要.
研究的目的:
- 调查TRT与脊椎骨折发生率之间的关联.
- 在接受TRT的患者中确定脊椎骨折的预测因子.
主要方法:
- 一项使用PearlDiver数据库的回顾性队列研究.
- 匹配的1:1对比 TRT 病史和没有 TRT 病史的患者.
- 多变量逻辑回归分析以确定脊椎骨折的独立预测因子.
主要成果:
- TRT与明显更高的脊椎骨折率 (0.31%对0.04%,P<0.001) 有关.
- 在接受TRT的男性和女性中观察到骨折率的增加.
- TRT,慢性病,滥用酒精和二酸盐使用是脊椎骨折的独立预测因素.
结论:
- 外源性的使用与脊椎骨折的发病率增加有关.
- 需要进一步的研究来确定因果关系.
- 对于患有脊椎骨折风险的患者,建议采取DEXA扫描等查措施.
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