在局部晚期宫癌患者用化学辐射和支臂疗法治疗的血栓预防
Lisa Leijtens1, Jurgen Piek1, An-Sofie Verrijssen2
1Department of Obstetrics and Gynecology Catharina Cancer Institute, Catharina Hospital, Eindhoven, the Netherlands.
Gynecologic oncology
|January 8, 2025
概括
高剂量的血栓预防疗法在接受化学辐射治疗的局部晚期宫癌 (LACC) 患者中有效减少静脉血栓栓塞事件 (VTE). 这项研究发现VTE的发病率很低,这表明例行预防是有益的.
科学领域:
- 妇科瘤学 妇科瘤学
- 血液学 血液学 血液学
- 放射治疗瘤学 放射治疗瘤学
背景情况:
- 接受化学辐射治疗的局部晚期宫癌 (LACC) 患者有风险发生静脉血栓塞栓事件 (VTE).
- 在治疗期间使用高剂量血栓预防,但其在这种人群中的有效性需要评估.
研究的目的:
- 确定LACC患者临床和亚临床静脉血栓栓塞事件 (VTE) 的发生率.
- 为了评估高剂量血栓预防在终极化疗和胸膜疗法期间的有效性.
主要方法:
- 一项前性观察性研究包括89名在2021年8月至2023年12月期间接受治疗的LACC患者.
- 患者接受高剂量血栓预防;在4-5周进行D-二次数水平和腿部静脉超声检查.
- 当需要时,CT血管图用于肺栓塞查.
主要成果:
- 临床和亚临床VTE的累计发病率为7.9% (7/89名患者).
- 深静脉血栓 (DVT) 在2名患者中发生,肺栓塞 (PE) 在3名患者中发生,并结合DVT/PE在1名患者中发生.
- 在3.4%的患者中发现亚临床VTE,在4.5%的患者中发现临床VTE. 动脉血栓栓塞事件 (ATE) 发生在一个患者身上.
结论:
- 在LACC患者的常规血栓预防显著降低了化学辐射和支臂治疗期间血栓栓塞事件的发生率.
- 未来的研究应该确定针对性VTE查和预防策略的高风险因素.
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