在患有永久性先天性甲状腺功能低下症的患者中,初潮的年龄和最终的身高
Pegah Karimian1,2, Silva Hovsepian3,4, Tahereh Alinia3
1School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Annals of pediatric endocrinology & metabolism
|January 8, 2025
概括
出生性甲状腺功能低下症 (CH) 患者经历了晚期青春期发作和初潮. 然而,及时治疗使这些年龄正常化,而延迟治疗与CH患者更高的初潮年龄有关.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖健康 生殖健康
- 遗传学和基因组学 遗传学和基因组学
背景情况:
- 先天性甲状腺功能低下症 (CH) 是一种从出生起影响甲状腺激素产生的疾病.
- 早期诊断和治疗对于CH患者的正常生长和发育至关重要.
- 了解CH对青春期发育的长期影响对于全面的患者护理至关重要.
研究的目的:
- 为了比较初潮时的年龄和永久性先天性甲状腺功能低下症 (CH) 的女性患者的最终身高标准偏差分数 (SDS) 与健康对照.
- 研究CH查相关变量和人口因素与CH患者初潮年龄和最终身高SDS的关联.
主要方法:
- 一项横截面研究比较了207名女性CH患者与598名健康的年龄相匹配的女性青少年.
- 评估青春期开始和初潮时的年龄,这些里程碑的身高和最终身高 (FH) 以及其SDS.
- 查变量和人体测量数据与初潮时的年龄和CH患者的FH SDS之间的关联的评估.
主要成果:
- 与健康对照组 (P<0.05) 相比,CH患者在青春期开始和初潮时表现出显著晚年的年龄.
- 在初潮时的平均身高,最终身高 (FH) 或其SDS中,在CH患者和对照者之间没有发现显著差异 (P>0.05).
- 在CH患者治疗开始时延迟的年龄与初潮时的更高年龄有关 (P=0.04),但与FH SDS无关.
结论:
- 虽然CH患者最初表现出延迟的初潮,但适当的治疗有效地使其正常化,使其与健康的同龄人保持一致.
- 在CH患者中,延迟开始治疗是与初潮晚年相关的关键因素.
- 治疗开始时的年龄成为影响CH患者初潮和青春期发生的唯一查相关变量.
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