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吸烟,酒精和代谢风险因素引起的胃肠道癌症的死亡率及其与社会经济发展状况的关联 2000-2021年
Pojsakorn Danpanichkul1, Kanokphong Suparan2, Yanfang Pang3
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.
The American journal of medicine
|January 8, 2025
概括
全球胃肠道 (GI) 癌症死亡人数从2000年到2021年增加了53.6%,主要是由于肥胖和酒精. 低收入国家现在承担了这一可预防的癌症负担的更大份额.
科学领域:
- 全球健康 全球健康
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 胃肠道 (GI) 癌症是一个重大的全球健康挑战,占全球癌症死亡人数的三分之一.
- 很大一部分胃肠道癌的病例是可以预防的,这凸显了需要了解可修改的风险因素的影响.
研究的目的:
- 更新归因于主要风险因素的肠胃癌的全球负担,包括吸烟,酒精,高体重指数 (BMI) 和高禁食血糖 (FBG).
- 分析从2000年到2021年胃肠道癌死亡率和年龄标准化死亡率的趋势.
- 检查这些趋势与各国的社会人口统计指数 (SDI) 相比,以了解差异.
主要方法:
- 利用了2021年全球疾病负担研究的数据.
- 检查了2000年至2021年间胃肠道癌死亡率和因吸烟,酒精,高BMI和高FBG而导致的年龄标准化死亡率的趋势.
- 分析了基于国家发展状况的趋势,使用社会人口统计指数 (SDI).
主要成果:
- 2021年,112万例胃肠道癌死亡与吸烟,酒精,高BMI和高FBG有关,自2000年以来增加了53.6%.
- 吸烟是主要原因 (43.3%),其次是酒精 (20.6%),高FBG (20.5%) 和高BMI (15.6%).
- 对于高BMI (+102.54%) 和高FBG (+107.69%),特别是肝癌和胰腺癌,观察到肠道癌死亡人数显著增加. 较低的SDI国家显示,全球GI癌症死亡率的比例越来越高,归因于这些风险因素.
结论:
- 在2000年至2021年期间,肠道癌死亡率在全球范围内大幅增加.
- 肥胖和酒精消费是导致肠胃癌死亡人数上升的主要驱动因素.
- 较低的SDI国家越来越多地对全球胃肠道癌症负担作出贡献,这表明疾病影响的转变.
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