不同肠道制备方案和年龄因素对肠道微生物群的影响:一项前性随机对照研究
Yuhang Zhou1,2, Huihui Ji2,3, Shuang Zhang2,4
1China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Journal of gastroenterology and hepatology
|January 8, 2025
概括
肠道制备显著减少了肠道微生物群的多样性,聚乙烯糖醇和硫酸盐显示出不同的恢复率. 年长的成年人 (≥65岁) 在手术后的微生物结构反弹更快.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 临床试验 临床试验
背景情况:
- 肠道准备对肠道微生物群的影响仍在争论中.
- 本研究涉及不同肠道制备方案对肠道微生物群组成和多样性的影响.
研究的目的:
- 为了研究聚乙烯糖醇和硫酸盐肠道制剂对肠道微生物群的影响.
- 为了比较不同年龄组的肠道微生物群的恢复模式在准备后.
主要方法:
- 这是一项前性随机对照试验,涉及194名患者.
- 在基线,第7天和第14天使用16S rRNA基因测序分析的便样本.
- 在两个制剂组和年龄组之间对微生物群的多样性和组成进行比较分析.
主要成果:
- 肠道准备导致肠道微生物群的丰富性和多样性显著下降,在第14天不完全恢复.
- 聚乙烯甘醇和硫酸盐组分别在丰富性和多样性方面表现出更快的恢复.
- 与年轻患者相比,65岁以上的个体显示微生物群结构恢复到基线的速度更快.
结论:
- 肠道微生物群的恢复因使用的肠道制备方案而异.
- 老年人 (≥65岁) 在肠道准备后,肠道微生物结构的恢复速度更快.
- 观察到β多样性的显著变化,老年人群的快速反弹显著.
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