在严重的社区获得性肺炎中使用类固醇的安全性
Federica Viola Piedepalumbo1,2,3, Ana Motos4,5,3, Francesco Blasi1,2
1Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
在严重的社区获得性肺炎 (sCAP) 中短期使用皮质类固醇似乎在感染和器官损伤方面是安全的. 然而,它可能会导致高血糖,需要仔细监测患者.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 针对严重社区获得性肺炎 (sCAP) 的全身性皮质类固醇,由于安全问题,存在临床困境.
- 目前对sCAP的皮质类固醇疗效和安全性的研究结果各不相同.
研究的目的:
- 审查目前关于sCAP患者短期皮质类固醇施用安全性的文献.
- 确定有关sCAP中类固醇使用的未来研究领域.
主要方法:
- 这篇叙述性综述分析了多项试验和对sCAP的皮质类固醇治疗的元分析的数据.
- 审查的重点是评估安全性,包括不良事件和疗效.
主要成果:
- 在sCAP中短期使用皮质类固醇与医疗相关感染,胃肠道出血或急性损伤的风险增加没有显著联系.
- 高血糖是显著的副作用,要求对接受类固醇的sCAP患者进行警监测和管理.
结论:
- 针对sCAP的短期皮质类固醇治疗通常被认为是安全的,对于感染和器官损伤等重大并发症而言.
- 需要进一步的研究,以了解类固醇在病毒性sCAP中的长期影响和风险.
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