基于多糖的结构和功能性质的定制策略,用于在炎症性肠病中提供营养
Jun Yang1, Jieqiong Lin2, Xianxiang Chen2
1School of Food Science and Engineering, Hainan University, Haikou 570228, China; State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China.
Carbohydrate polymers
|January 8, 2025
概括
自然的多糖制剂创造了先进的食品输送系统 (FDS),以提高营养物质的溶解性,稳定性和生物可用性. 这些基于多糖的口服输送系统 (PODS) 为改善营养提供了量身定制的特性,特别是在炎症性肠道疾病中.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物材料科学 生物材料科学
- 营养科学 营养科学
背景情况:
- 许多必需的食品营养素面临限制,包括水溶性差,稳定性低,生物可用性不足.
- 基于食物的输送系统 (FDS),利用食物传播的大分子,为克服这些营养挑战提供了一个有希望的解决方案.
- 由于其生物活性,功能性质和生物相容性,天然多糖类被青为FDS.
研究的目的:
- 审查自然多糖的应用在开发各种FDS及其功能性质.
- 探索定制基于多糖的口服输送系统 (PODS) 具有特定特性 (形状,大小,电荷,准) 的策略.
- 突出PODS在解决营养缺乏症方面的优势及其在炎症性肠病营养干预中的作用.
主要方法:
- 关于FDS开发中使用的天然多糖类的综合文献综述.
- 分析结构-财产关系,以定制PODS特征.
- 在稳定性,毒性,粘附性,细胞吸收,保留和释放行为方面评估PODS性能.
主要成果:
- 天然多糖可使多样化的FDS发展,改善营养物质的输送能力.
- 根据多糖体的结构特征 (溶解度,离子类型,分子量) 和生物活性,可定制PODS属性.
- PODS在提高胃肠道环境中的营养物质生物可用性方面显示出显著的潜力.
结论:
- 天然多糖是开发有效的基于食品的输送系统的多功能生物材料.
- 基于多糖的口服输送系统 (PODS) 可以精确设计,以满足特定的营养和治疗需求.
- PODS显示出营养干预措施的前景,特别是在管理炎症性肠病和相关的营养缺乏方面.
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