准备,表征,稳定性和补充能力的Moringa oleifera叶片酸叶片酸盐
Deying Men1, Jiahe Dai2, Zhongyuan Lei1
1College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Food research international (Ottawa, Ont.)
|January 8, 2025
概括
来自Moringa oleifera叶蛋白 (MORP-Ca) 的酸可作为一种新补充剂. 在动物研究中,MORP-Ca增强的吸收,改善骨健康,并积极调节肠道微生物群.
科学领域:
- 营养生物化学 营养生物化学
- 食品科学 食品科学 食品科学
- 生物技术是生物技术.
背景情况:
- 缺乏是全球重要的健康问题.
- 酸酸代表了一类新的补充剂,具有潜在的市场增长.
- 莫林加 (Moringa oleifera) 是一种含有潜在生物活性化合物的植物来源.
研究的目的:
- 来自Moringa oleifera叶蛋白 (MORP) 的新型基酸 (MORP-Ca) 的生产和特征.
- 评估MORP-Ca.的稳定性,运输和促进吸收的作用.
- 在体内调查MORP-Ca对骨健康和肠道微生物群的影响.
主要方法:
- 进行Moringa oleifera叶蛋白的酶性水解以产生MORP (MW < 1 kDa).
- 用Ca2+对MORP进行化,形成MORP-Ca.
- 使用SEM,EDS,FTIR和FS进行结构性表征.
- 在体外细胞实验中进行运输评估.
- 在体内动物研究 (老鼠) 评估骨矿物质密度,骨形成和肠道微生物群的变化.
- 为了的识别,LC-MS/MS和分子对接.
主要成果:
- MORP-Ca形成涉及MORP的功能组并改变其结构.
- MORP-Ca的胃稳定性很差,但肠道和热稳定性很高.
- 在细胞模型中,MORP-Ca有效促进的运输和吸收.
- 在动物模型中,MORP-Ca补充剂增加了骨矿物质密度和骨形成.
- MORP-Ca调节了肠道微生物群,增加了Firmicutes,减少了Actinobacteria.
- 确定了关键的结合序列 (例如,ARNEGRDL).
结论:
- MORP-Ca是一种结构特征的基酸,在肠道中具有增强的稳定性.
- MORP-Ca有效地增强的吸收,骨健康,并调节肠道微生物群.
- 已识别的序列为MORP-Ca的疗效提供了分子基础.
- MORP-Ca具有作为功能性食品成分或补充剂的潜力.
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