持续体征症状患者症状严重程度,身体和精神功能的五年轨迹:PROSPECTS队列研究
Hieke Barends1,2, Henriëtte E van der Horst3,2, Johannes C van der Wouden3,2
1Department of General Practice, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands h.barends@amsterdamumc.nl.
BMJ open
|January 8, 2025
概括
大多数患有持续体征症状 (PSS) 的患者在五年内经历了稳定,严重的症状和身体和精神功能有限的改善. 在这些长期PSS轨迹中,患者的特征各不相同.
科学领域:
- 精神病学是一个精神病学.
- 一般实践 一般实践
- 纵向健康研究 纵向健康研究
背景情况:
- 持续的体征症状 (PSS) 显著影响患者的生活,需要更好地了解他们的长期病程.
- 诊断和PSS的长期结果对于明智的临床决策和患者指导至关重要.
研究的目的:
- 在患有PSS的成年患者中,确定症状严重程度,身体功能和精神功能的独特的5年轨迹.
- 探索与这些已识别的轨迹相关的患者特征,以潜在的早期识别.
主要方法:
- 利用了PROSPECTS研究的纵向数据,该研究涉及5年时间内的7项测量,对成人PSS患者进行测量.
- 应用潜伏类生长混合模型,以辨别症状严重程度,身体功能和精神功能的不同轨迹.
- 包括297名从荷兰的全科医院和专门的PSS治疗设施招募的参与者.
主要成果:
- 症状严重程度的两个稳定轨迹:"严重症状,稳定" (15.8%) 和"中度症状,稳定" (84.2%).
- 身体功能有三个轨迹:"身体功能差,明显改善" (8.5%),"身体功能差,稳定" (34.7%) 和"身体功能中等,略有改善" (56.8%).
- 精神功能有三个轨迹:"精神功能差,明显改善" (13.9%),"精神功能中等,恶化" (12.2%),以及"精神功能中等,略有改善" (73.8%).
- 患者的特征,包括背景,压力因素,并发症和应对反应,在确定的轨迹上有很大的差异.
结论:
- 在成年PSS患者中,确定了症状严重程度,身体和精神功能的明显的5年轨迹.
- 结果表明,大多数PSS患者的持续症状和有限的功能改善的患病率很高.
- 一小部分患者表现出明显的改善或恶化,具有不同的特征,可能有助于早期识别,尽管需要进一步的预测研究.
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