沙特阿拉伯炎症性肠病的肝胆表现:一个回顾性分析
Murad M Aljiffry1, Bayan M Dahal1, Razana S Baeisa1
1From the Department of Surgery (Aljiffry, Dahal, Baeisa, Alzahrani, Saleem, Alshahrany), from the Department of Medicine (Hijji, Alsahafi, Alghamdi, Mosli), from the Faculty of Medicine (Aljiffry, Daha, Baeisa, Alzahrani, Alshahrany, Hijji, Alsahafi, Saleem, Alghamdi, Mosli), King Abdulaziz University, from the Inflammatory Bowel Disease Research Group (Alsahafi, Mosli), and from the Gastrointestinal Oncology Unit (Saleem, Alghamdi), King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
肝胆道疾病影响的炎症性肠病 (IBD) 患者的比例很小,而原发性硬化性胆道炎 (PSC) 是最常见的. 密切监测至关重要,特别是对于那些接受抗TNF治疗的人来说.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 包括克罗恩病 (CD) 和性结肠炎 (UC).
- 肝胆道并发症是公认的,但在IBD人群中未得到充分研究.
- 在IBD中早期识别和治疗肝病对于患者的治疗结果至关重要.
研究的目的:
- 确定IBD患者肝胆道疾病的频率和特征.
- 确定与这些肝脏表现的发展相关的潜在预测因素.
- 加强IBD患者的临床监测策略.
主要方法:
- 在国王阿卜杜勒阿齐兹大学医院对885名IBD患者的回顾性分析.
- 评估原发性硬化性胆道炎 (PSC),非酒精性脂肪性肝病 (NAFLD) 和自身免疫性肝炎 (AIH) 的流行情况.
- 使用后勤回归分析来确定肝胆道疾病的预测因素.
主要成果:
- 在4.3%的IBD患者中观察到肝胆道表现,性结肠炎 (UC) 的相关性较高 (65.8%),而克罗恩病 (CD) 的相关性较高 (31.6%).
- 原发性硬化性胆道炎 (PSC) 是最常见的肝胆道疾病,特别是在女性中,与左侧UC和大肠直肠CD相关.
- 结核病诊断,阿达利穆马布和因弗力西马布使用与PSC的几率增加有关,而伴随性疾病的缺乏与更低的几率相关.
结论:
- 肝胆道并发症发生在少数IBD患者中,PSC是主要的疾病.
- 这些发现强调了对IBD患者肝脏健康的警监测的必要性.
- 由于增加PSC风险,应特别注意接受抗TNF治疗的IBD患者.
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