检索一个乙醇条件的味道厌恶促进GABAergic可塑性在前部岛屿皮层
Lisa R Taxier1, Sofia Neira1, Meghan E Flanigan1
1Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599.
概括
检索以乙醇为条件的味觉厌恶 (CTA) 记忆会增加前岛皮层 (aIC) 到底侧杏仁体 (BLA) 路径中的抑制神经活动. 这种神经可塑性可能会影响乙醇消费的动机.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 行为神经科学 行为神经科学
背景情况:
- 对乙醇厌恶作用的敏感性降低与乙醇消费增加有关.
- 编码乙醇厌恶性质的神经生物学基础仍然不完全理解.
- 前部岛内皮层 (aIC) 到底侧杏仁体 (BLA) 电路与味觉厌恶学习有关.
研究的目的:
- 为了研究GABAergic电流在aIC→BLA投影中的作用,以乙醇为条件的味觉厌恶 (CTA) 检索.
- 为了测试GABAergic电流在乙醇-CTA检索后被促进的假设.
主要方法:
- 在aIC→BLA投射神经元中微型抑制后突触电流 (mIPSC) 的电生理学记录.
- 对2/3层aIC→BLA神经元的抑制输入的评估.
- 使用DREADDs进行化学遗传操纵,以抑制小鼠中的aIC帕瓦胺表达细胞.
主要成果:
- 在乙醇-CTA检索后1小时,aIC→BLA投射神经元中的mIPSC频率增加.
- 在乙醇-CTA之后,增加了局部抑制输入的数量和强度,进入2/3层aIC→BLA神经元.
- 在男性中抑制aIC帕瓦胺细胞影响了乙醇-CTA检索,但在女性中却没有.
结论:
- 乙醇-CTA的记忆检索会在aIC→BLA路径中诱导特定于电路的,时间有限的和取决于检索的GABAergic可塑性.
- 在乙醇-CTA检索后抑制基调的增加有助于编码乙醇的厌恶效应.
- 这些发现有助于更好地了解底层乙醇厌恶和消费动机的神经机制.
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