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Updated: Jun 3, 2025

A High-content Assay for Monitoring AMPA Receptor Trafficking
10:34

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

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氨基酸β驱动的突触缺陷是通过突触去除含有GluA3的AMPA受体进行介导的

Niels R Reinders1,2,3,4, Sophie J F van der Spek3, Remco V Klaassen3

  • 1Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam 1105 BA, The Netherlands h.w.h.g.kessels@uva.nl n.r.reinders@uu.nl.

The Journal of neuroscience : the official journal of the Society for Neuroscience
|January 8, 2025
PubMed
概括

阿尔茨海默病涉及粉样蛋白-β (Aβ) 寡合体破坏突触. 研究人员发现,含有GluA3的AMPA受体是关键的,因为它们被Aβ寡合体降解会导致突触缺陷.

关键词:
这是一个AMPAPAAMPA.这就是阿尔茨海默病的原因.GluA3; PDZ 域名域名氨基化物 氨基化物突触突触是指突触中的突触.

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