基于母体和脂肪酸的欧性溶剂作为黄素的可溶性和稳定性增强剂
Zhuoni Liu1, Xianshuo Zhang2, Xiaoyong Wang1
1School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
The journal of physical chemistry. B
|January 8, 2025
概括
新的欧性溶剂 (ESs) 显著增加了黄素.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物化学 生物化学
背景情况:
- 欧性溶剂 (ESs) 提高了活性药物成分 (API) 的可溶性,稳定性和生物活性.
- 黄素是一种天然的API,具有抗菌,抗炎和抗癌特性,但溶解性和稳定性不佳.
- 这些局限性阻碍了黄素的临床应用.
研究的目的:
- 开发使用母蛋白和脂肪酸 (乙酸,乙酸,酸) 的新型欧溶剂 (ESs).
- 调查开发的ESs的相位行为和细胞毒性.
- 评估这些ESs在提高黄素的可溶性,稳定性和生物活性方面的有效性.
主要方法:
- 从母蛋白和脂肪酸合成新型欧阳性溶剂 (ESs).
- 调查ESs的相位行为和细胞毒性.
- 库尔库在ESs中的可溶性,稳定性,抗氧化剂和抗菌性评估.
主要成果:
- 实验表明,黄素的溶解性得到了很好的提高,在298K时达到28mg/mL (与水相比增加了5万倍).
- 黄素在ES中表现出很高的稳定性,在6小时的光照照射下仅有10%的分解.
- 使用ESs制备的基于黄素的生物膜显示出显著的抗氧化和抗菌活性.
结论:
- 基于母体脂肪酸的新型欧性溶剂有效地提高了黄素的可溶性和稳定性.
- 这些ES提供了一个有前途的策略,用于增强黄素的制药应用.
- 开发出来的感系统为利用黄素的治疗潜力提供了新的途径.
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