基于薄荷的新型超可变形囊泡:一种抗真菌药物的配方,优化和评估

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Hema Manjushree¹, Devika Nayak¹, Praveen Halagali¹

¹Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576107, India.

AAPS PharmSciTech

|January 8, 2025

概括

这项研究开发了带有可纳的薄荷体,一种新型的超可变形囊泡系统. 这些薄荷体显著增强皮肤药物透和抗真菌活性对抗白菌.

科学领域:

药品制造药品制造药品制造
药物输送系统药物输送系统
皮肤病学皮肤病学

背景情况:

凯托可纳是一种抗真菌剂,具有有限的皮肤透能力.
开发有效的局部输送系统对于治疗皮肤真菌感染至关重要.
薄膜体具有作为超可变形囊泡的潜力,可以增强通过皮肤传递.

研究的目的:

为了配制和表征含有基托可纳的薄荷体.
评估薄荷体配方增强的皮肤透和抗真菌功效.
建立薄荷体作为改善局部抗真菌疗法的强有力的载体.

主要方法:

使用薄膜蒸发和水化技术制备了加可纳的薄膜.
为了优化配方参数,采用了2 ^ 3的全因数设计.
描述包括囊泡大小,多分散度指数 (PDI),捕获效率 (% EE) 和泽塔潜力.
进行了ex vivo皮肤透,体外药物释放,体外抗真菌和体内药学动力学研究.

主要成果:

优化的薄荷体批次显示了囊泡大小为107.6nm,PDI为0.248,%EE为76.9%,而zeta潜力为-33.7mV.
与对照配方相比,观察到增强的ex vivo皮肤透和体外药物释放.
优化的配方在体外表现出优异的抗真菌活性,在体内表现出对Candida albicans的药理学有效性.

结论:

含有基托可纳的薄荷体代表了一个有前途的超可变形囊系统.
门托索姆显著改善了药物通过皮肤的透.
这种新的系统增强了抗真菌活性,为局部治疗真菌感染提供了有效的策略.

关键词:

基于脂质的配方薄荷荷组是一种薄荷组.透增强剂是一种透增强剂.通过皮肤通过皮肤.

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