死亡率,肝衰竭和心血管结果在瘦与非瘦的MASLD肝硬化:退伍军人事务队列研究
Basile Njei1, Catherine Mezzacappa1, Binu V John2
1Section of Digestive Diseases, Yale University School of Medicine/VA Connecticut Healthcare System, New Haven, CT, USA.
Digestive diseases and sciences
|January 8, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 肝硬化症的瘦肉患者面临更高的死亡率,但肝脏衰退的风险较低. 尽管身材更好,但患有MASLD肝硬化的瘦个体却增加了心血管死亡率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球25%.
- 瘦与非瘦MASLD患者的结果仍在争论中.
- 这项研究比较了瘦身和非瘦身MASLD肝硬化患者的结果.
研究的目的:
- 为了比较瘦身和非瘦身个体与补偿MASLD肝硬化之间的事件临床结果和死亡率.
- 分析肝脏衰竭,主要心血管不良事件 (MACE) 和全因死亡率的风险.
主要方法:
- 对15155名新诊断的弥补MASLD肝硬化患者进行了回顾性队列研究 (01/2008-05/2021).
- 主要结局:发生的肝脏不补偿.
- 二次结果:发生的MACE和所有原因的死亡率.
- 使用多变量Cox比例危险模型和Fine&Gray竞争风险回归.
主要成果:
- 精益 MASLD 肝硬化患者 (1,597) 的基线糖尿病患病率较低 (46.7%与73.9%相比).
- 瘦身状态与64%的全因死亡率 (aHR=1.64) 和较高的心血管死亡率 (aHR=1.40) 的风险增加有关.
- 瘦个体显示,尽管MACE的发病率相似,但肝脏衰退的风险降低 (aSHR=0.67).
结论:
- 瘦身 MASLD 肝硬化患者的整体死亡风险较高,但肝脏不补偿的风险较低.
- 尽管基线心脏代谢概况更健康,但患有MASLD肝硬化的瘦个体面临心血管死亡率升高.
- 这些发现突出了基于MASLD肝硬化体质指数的独特结果轨迹.
更多相关视频
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
1.1K
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
770
相关概念视频
01:26Diseases of the Liver and Gallbladder
429
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
429
01:24Overview of Lipid Metabolism
1.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.0K