科里尼细菌角膜炎的临床和细菌学特征
Hidenori Inoue1, Koji Toriyama2, Shinobu Murakami3
1Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan. inoue.hidenori.yo@ehime-u.ac.jp.
Journal of ophthalmic inflammation and infection
|January 8, 2025
概括
科里尼细菌角膜炎呈现为附着或透性病变,通常与之前的诺基诺和类固醇眼滴使用有关. 在Corynebacterium macginleyi中观察到对诺基诺的高耐药性,需要进行类治疗.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 科里尼菌种在人体皮肤和粘膜上很常见.
- 这些细菌被认为是导致眼部感染的重要病原体.
- 了解Corynebacterium角膜炎的临床谱对于有效管理至关重要.
研究的目的:
- 为了研究由Corynebacterium物种引起的细菌性角膜炎的临床特征.
- 要区分粘附性和透性类型的Corynebacterium角膜炎.
- 为了确定与这种感染相关的风险因素和治疗结果.
主要方法:
- 埃希梅大学医院细菌性角质炎病例的回顾性审查 (2010年1月 - 2024年2月).
- 收录标准:从角膜片中单独分离出Corynebacterium物种.
- 角膜炎的分类为附着性 (角膜表面粘附) 和透性 (透性透) 类型.
主要成果:
- 在培养阳性细菌性角膜炎病例中,科里尼细菌占9.9% (23/232).
- 附着型 (56.5%) 比透型 (43.5%) 更常见.
- 观察到高诺基诺耐药性 (91%),特别是在Corynebacterium macginleyi (所有分离物耐药).
- 患者往往有诺基诺 (60.9%) 和类固醇 (52.2%) 眼滴使用史.
- 治疗主要涉及塞法洛斯波林眼滴,平均持续时间为21.6天;五个附着病例需要除菌.
结论:
- 科里尼细菌角膜炎表现为不同的附着性和透性病变类型.
- 之前使用诺基诺和类固醇眼滴是患者的关键特征.
- 诺基诺抗性的高患病率需要仔细选择治疗的抗生素.
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