相关实验视频
Updated: Jun 3, 2025

07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
12.4K
将基因疗法纳入非肌肉侵入性膀癌的治疗范式
Alexis R Steinmetz1, Behzad Jazayeri2, Morgan Pierce1
1Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Expert opinion on biological therapy
|January 8, 2025
概括
基因疗法为非肌肉侵入性膀癌 (NMIBC) 提供了一个有希望的新途径,有可能克服对现有治疗方法的耐药性. 研究正在推进用于NMIBC管理的已批准和正在研究的基因疗法.
科学领域:
- 在瘤学瘤学.
- 基因治疗 基因治疗
- 泌尿器细胞癌的癌症.
背景情况:
- 非肌肉侵入性膀癌 (NMIBC) 占诊断病例的约75%.
- 对NMIBC的药物开发历来面临着挑战,克服治疗耐药性和预防复发的选择有限.
- 基因疗法正在成为NMIBC管理的新且有前途的治疗策略.
研究的目的:
- 在NMIBC中审查基因治疗的临床应用.
- 讨论最近对基于腺病毒载体的基因疗法的临床试验,包括纳多法拉基因firadenovec和克雷托斯蒂莫基因grenadenorepvec.
- 探索增强NMIBC基因疗法的疗效和耐用性的策略.
主要方法:
- 对NMIBC基因治疗的临床试验和文献的审查.
- 基于腺病毒载体的治疗方法最近的进展概述.
- 对正在进行的研究分析,研究组合疗法和新药.
主要成果:
- 纳多法基因firadenovec在2022年12月获得FDA批准.
- 克雷托斯蒂摩根格拉纳登诺雷普韦克已经获得了FDA的快速跟踪和突破性治疗指标.
- 基因疗法显示出克服抵抗机制的潜力,并且可能与其他药物结合使用时有效.
结论:
- 基因疗法代表了NMIBC治疗的重大进步,提供了一种克服药物耐药性的新方法.
- 目前正在进行的研究重点是提高基因疗法的疗效和耐用性,对各种患者群体的兴趣日益扩大.
- 对试验设计进行批判性评估是必要的,以比较不同的基因治疗药物,并为未来的临床实践提供信息.
相关概念视频
Gene Therapy
25.2K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.2K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Tumor Immunotherapy
472
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
472
Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

