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Updated: May 12, 2026

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多模式无细胞DNA全基因组TAPS是敏感的,并揭示特定的癌症信号

Dimitrios V Vavoulis1,2, Anthony Cutts3, Nishita Thota4

  • 1Oxford Molecular Diagnostics Centre, Department of Oncology, University of Oxford, Oxford, UK. dimitris.vavoulis@oncology.ox.ac.uk.

Nature communications
|January 8, 2025
PubMed
概括

这项研究引入了一种新的全基因组测序方法,用于在液体活检中分析循环瘤DNA (ctDNA). 该方法在多种癌症的检测和监测中实现了高精度,即使在低ctDNA水平.

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...