在异性造血干细胞移植期间,ESBL殖民状态对肠道微生物群组成的影响
Silvia Corcione1,2, Ilario Ferrocino3, Tommaso Lupia4
1Department of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy. silvia.corcione@unito.it.
Scientific reports
|January 8, 2025
概括
与扩展光谱β-乳糖酶 (ESBL) 细菌结合的全源造血干细胞移植 (allo-HSCT) 患者表现出明显的肠道微生物组特征. 这项试点研究揭示了细菌丰富性的差异,影响了移植后的肠道健康.
科学领域:
- 微生物学 微生物学
- 血液学 血液学 血液学
- 胃肠病学 胃肠病学
背景情况:
- 全基性造血干细胞移植 (allo-HSCT) 与肠道微生物群多样性的显著减少有关.
- 化疗,抗生素和炎症是后合-HSCT失生症的主要驱动因素.
- 扩展光谱β-乳糖酶 (ESBL) 细菌殖民在接受allo-HSCT.患者中很常见.
研究的目的:
- 在接受allo-HSCT的患者中调查肠道微生物群组成的变化.
- 为了确定ESBL殖民是否影响肠道微生物群多样性,在 allo-HSCT.
- 为了比较ESBL殖民和非殖民患者之间的微生物群概况.
主要方法:
- 在一个单一中心进行潜在的试点研究.
- 从入院到HSCT1年后,每周收集便样本.
- 微生物群组成分析并比较了殖民和非殖民患者.
主要成果:
- 患有ESBL细菌的患者表现出比菲多细菌,蓝病,菌,菌,L-Ruminococcus,Mogibacteriaceae,Peptostreptococceae和Oscillospira的丰度较高.
- 不被殖民的患者表现出更多的Actinomycetales,Staphylococcus和Sutterella.
- 在HSCT后保留ESBL殖民的患者中,阿克尔曼西亚,利斯特,Erysipelotrichaceae和Methanobrevibacter的增加.
结论:
- 在Allo-HSCT患者中,ESBL殖民与特定的肠道微生物群组成有关.
- 微生物群的形状因ESBL的殖民状态和持续性而有所不同.
- 进一步的研究将探索肠道屏障功能和SCFA生产,以预测临床结果.
更多相关视频
14:43Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
Published on: October 1, 2012
18.3K
07:45Preparation and Maintenance of Bioexclusion IsoPositive Cage Experiment for Human Fecal Transplantation into Germ-Free Mice
Published on: February 28, 2025
256
相关概念视频
01:22Bone Marrow Sampling and Transplants
279
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
279
01:01Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K