在系统性红斑狼和认知障碍的系统性红斑狼中,大脑输液和相应的大脑功能网络的改变
Huiyang Liu1, Hu Liu1, Bailing Tian2
1Department of Radiology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Scientific reports
|January 8, 2025
概括
系统性红斑狼 (SLE) 认知障碍 (CI) 患者表现出大脑血液流动和连接的改变. 这些神经成像发现可能有助于识别SLE-CI的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 认知障碍 (CI) 在全身性红斑狼 (SLE) 中很常见.
- 在SLE与CI (SLE-CI) 中潜在的大脑血液动力学变化尚不清楚.
- 神经炎症和神经血管变化是SLE中CI的可疑原因.
研究的目的:
- 调查SLE患者的脑血液动力学和功能连接,无论是有或没有认知障碍.
- 为了确定潜在的神经成像生物标志物用于SLE的认知功能障碍.
主要方法:
- 97名SLE患者和51名健康对照 (HCs) 接受了MRI,包括3D T1加权,动脉旋转标记 (ASL) 和静止状态功能MRI (rs-fMRI).
- 分析了脑血流 (CBF) 和基于种子的功能连接 (FC).
- 用蒙特利尔认知评估 (MoCA) 评估认知状态.
主要成果:
- 与没有CI (SLE-NC) 的SLE患者相比,患有CI (SLE-CI) 的SLE患者在左海马,丘脑和小脑Crus II中表现出更高的CBF,在左额叶中表现出更低的CBF.
- 患有SLE-CI的患者在左侧胰周和左侧小脑 II.crus之间增加了FC.
- 在SLE-CI患者的左海马和同侧副海马之间观察到降低FC.
结论:
- 改变大脑血流和功能网络连接性与SLE的认知障碍有关.
- 这些神经成像发现,包括CBF和FC的变化,可以作为SLE-CI的潜在生物标志物.
- 进一步的研究可以探索这些生物标志物的诊断和预后价值.
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