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Updated: Jun 3, 2025

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
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使用SAM的 ribozyme SAMURI的结构和催化活性

Hsuan-Ai Chen1, Takumi Okuda1, Ann-Kathrin Lenz1

  • 1Institute of Organic Chemistry, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.

Nature chemical biology
|January 8, 2025
PubMed
概括

这项研究揭示了SAMURI的晶体结构,SAM是一种利用S-adenosylmethionine (SAM) 修改RNA的 ribozyme. 这些结构解释了SAMURI如何实现特定位点的化,并避免自我甲基化,与天然的核糖开关不同.

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