对于长期COVID和超重的人来说,远程传递体重管理:随机等候名单控制的ReDIRECT试验
Emilie Combet1, Laura Haag2, Janice Richardson3
1Human Nutrition, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK. emilie.combetaspray@glasgow.ac.uk.
Nature medicine
|January 8, 2025
概括
一个结构化的体重管理计划改善了超重成年人的长期COVID症状. 这种远程干预为管理持续性后病毒性疾病提供了潜在的新治疗途径.
科学领域:
- 医学研究 医学研究
- 临床试验中的临床试验.
- 公共卫生 公共卫生
背景情况:
- 长期COVID (LC) 是一种复杂,多症状的疾病,缺乏疾病修饰治疗.
- 超重的LC患者可能会受益于针对体重管理的干预措施.
- 医疗保健干预措施的远程交付越来越重要.
研究的目的:
- 评估远程传递的结构化体重管理计划对改善长期COVID症状的有效性.
- 评估干预对主要结果的影响,如疲劳,喘息,疼痛或焦虑/抑郁.
主要方法:
- 一个等候名单控制的开放性试验随机将234名患有LC和超重的成年人分配到体重管理计划或通常的护理中.
- 这项干预涉及为期12周的全方位饮食替代,随后进行体重维持支持.
- 通过使用经过验证的问卷和视觉模拟尺度在6个月后评估初级结果.
主要成果:
- 与对照组相比,干预组在首要症状结果上表现出更大的改善 (治疗效果 -0.34,95% CI -0.67至 -0.01).
- 干预组中没有观察到过多的严重不良事件.
- 该计划通过远程传递,证明了长期COVID管理的可行性.
结论:
- 远程传递的结构化体重管理计划可以有效地改善超重个体的长期COVID症状.
- 这种干预代表了一种有希望的,非药物治疗方法来管理长期COVID.
- 进一步的研究应该探索长期影响和更广泛的适用性.
相关概念视频
Obesity
372
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
372
Clinical Trials
6.6K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.6K
Clinical Trials: Overview
2.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.7K
COPD: Management Using Bronchodilators and Corticosteroids
177
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
177
Chronic Obstructive Pulmonary Disease-V: Management
2.5K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
2.5K
Binge Eating Disorders
47
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
47


