对比基因组学的一种基因组学方法

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Updated: Jun 3, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

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Anna E Dewar1,2, Laurence J Belcher3, Stuart A West3

  • 1Department of Biology, University of Oxford, Oxford, UK. anna.dewar@biology.ox.ac.uk.

Nature reviews. Genetics
|January 8, 2025
PubMed
概括

基于系谱的方法对于比较基因组学至关重要,确保对物种之间的遗传和进化关系进行准确的分析. 对进化历史的计算解决了基因组数据中的非独立性问题,彻底改变了生物学见解.

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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