为75岁及以上的亚洲成年人开发和验证为期五年的心血管风险评估工具
Meng-Chen Hsu1, Yu-Hua Fu1, Chi-Chuan Wang1,2,3
1Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei, 100025, Taiwan.
BMC geriatrics
|January 8, 2025
概括
这项研究为75岁以上的亚洲老年人开发了一种特定于性别的心血管风险工具. 该工具显示出预测心血管疾病 (CVD) 风险的能力,有助于针对这一群体进行有针对性的干预.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 在75岁及以上的亚洲老年人中确定了心血管 (CV) 风险因素.
- 旨在为这一群体开发和验证特定于性别的五年CV风险评估工具.
研究的目的:
- 在75岁及以上的亚洲老年人中确定心血管风险因素.
- 为这一群体开发和验证一个特定于性别的五年心血管风险评估工具.
主要方法:
- 包括12174名年龄≥75岁且在台湾没有先前心血管疾病的患者.
- 使用电子健康记录与国家数据库链接,以获得全面的数据.
- 使用考克斯回归建模开发了一种特定于性别的心血管风险评估工具,数据分为导出 (80%) 和验证 (20%) 队列.
主要成果:
- 确定了男性 (年龄,吸烟,高非HDL-C,癌症,阿司匹林) 和女性 (年龄,吸烟,心房动,癌症,痴呆症,骨关节炎,SLE,抗高血压药,口服抗凝药) 的不同CV风险预测因素.
- 性别特定的风险评估工具在验证队列中显示出公平的歧视力 (AUC:男性,0.64;女性,0.68).
- 模型校准对女性来说是好的,但对男性来说不太理想.
结论:
- 一种特定于性别的心血管风险评估工具显示出对估计老年亚洲人心血管疾病风险的公平歧视能力.
- 这种工具有可能为这个脆弱的人群提供有针对性的干预措施.
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