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肥胖和自杀死亡风险之间的反向关联
Joonyub Lee1, Seung-Hwan Lee1, Mee-Kyoung Kim2
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
BMC psychiatry
|January 8, 2025
概括
体重不足的人面临更高的自杀死亡风险,而超重和肥胖的人显示风险降低. 身体质量指数和自杀死亡风险之间的反向相关性是独立于严重抑郁症或生活情况.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 精神病学是一个精神病学.
背景情况:
- 自杀是一个重要的公共卫生问题,是可以预防的.
- 体重指数 (BMI) 是一个关键的健康指标,但它与自杀死亡风险的联系需要进一步研究,特别是在非西方人群中.
- 了解BMI和自杀性死亡之间的复杂关系对于公共卫生干预至关重要.
研究的目的:
- 调查身体质量指数 (BMI) 与大量成年人群中自杀死亡风险之间的联系.
- 分析与BMI相关的自杀死亡风险,考虑潜在的混因素.
主要方法:
- 一项全国性的,回顾性,观察性研究,使用韩国国家医疗保险服务的数据,从4,045,081名19岁以上的成年人 (2009) 的数据.
- 参与者根据BMI进行分类:体重不足 (<18.5),正常 (18.5-23),超重 (23-25),I类肥胖 (25-30),II类肥胖 (>30).
- 多变量考克斯比例危险回归分析了自杀死亡风险 (ICD-10代码X60-X84),调整了年龄,性别,收入,并发症,生活方式因素和心理健康状况.
主要成果:
- 体重不足的人与正常体重的人相比,自杀死亡风险增加了44% (HR 1.44,95% CI 1.31-1.57).
- 超重 (HR 0.79),I类肥胖 (HR 0.76) 和II类肥胖 (HR 0.71) 与自杀死亡风险降低有关.
- 这些与BMI相关的风险模式持续不论主要抑郁症 (MDD) 或生活安排.
结论:
- 自杀死亡风险与BMI相反相关,独立于MDD或生活安排.
- 与体重相关的生理因素在自杀死亡风险中起着重要作用.
- 调查结果为优先考虑公共卫生资源提供了洞察力,以减轻自杀死亡率.
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