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在中国2型糖尿病中使用不同的查指数预测MASLD

Mengmeng Hu¹, Jingyu Yang¹, Beibei Gao¹

¹Department of Endocrinology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 126 Daoqian Street, Suzhou, 215000, China.

Diabetology & metabolic syndrome

|January 9, 2025

概括

脂质积累产品 (LAP) 指数是预测2型糖尿病的中国患者代谢功能障碍相关脂肪性肝病 (MASLD) 的可靠工具. 这一发现支持早期,非侵入性检测MASLD.

科学领域:

肝病学肝病学是一种肝病学.
代谢疾病代谢疾病
糖尿病研究糖尿病研究

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是全球慢性肝病的主要原因.
2型糖尿病 (T2DM) 是发展MASLD的一个重要风险因素.
早期发现MASLD对于有效管理和预防并发症至关重要.

研究的目的:

评估9个不同的指数对中国T2DM患者的MASLD的预测能力.
在这个人群中确定查MASLD最有效的非侵入性指数.
为了比较单个和复合预测指数的表现.

主要方法:

一项对苏州市立医院1,742名T2DM患者的横截面研究.
通过腹部超声波检查证实了MASLD的诊断.
进行了后勤回归和ROC曲线分析,以评估各种指数的预测准确性.

主要成果:

所有九个评估指数 (VAI,TyG,HOMA-IR,BMI,LAP,WHtR,TyG-BMI,TyG-WC,TyG-WHtR) 都显示出与MASLD风险的积极关联.
脂质积累产品 (LAP) 显示出最高的预测值 (AUC=0.786),紧随其后的是BMI (AUC=0.785).
像TyG-BMI这样的复合指数也表现出显著的预测能力.

结论:

所有九个指数都与MASLD风险有良好的相关性,并显示出良好的预测性能.
LAP被认为是预测中国T2DM患者MASLD的可靠指标.
这些发现支持使用非侵入性查工具来早期检测MASLD.

关键词:

这就是为什么BMI是BMI.在HOMA-IR中,我们可以看到HOMA-IR.拉普拉普 (LAP) 是一个地方.马斯尔德马斯尔德是什么意思这就是T2DM.在 TyG 里面,你会看到 TyG.在TyG-BMI中.在TyG-WC中使用.在TyG-WHtR中.这就是VAI VAI.这是什么?WHtR

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