免疫检查点抑制剂的安全性和有效性在治疗前左心室功能减弱的患者中
Maor Tzuberi1,2, Rafael Y Brzezinski1,2, Nir Flint1,2
1Division of Cardiology, Tel Aviv Sourasky medical Center, Tel Aviv, Israel.
Cardio-oncology (London, England)
|January 9, 2025
概括
免疫检查点抑制剂 (ICI) 是有效的癌症治疗方法. 治疗前减少的左心室喷射率 (LVEF) 不能独立预测接受ICI的患者的心血管事件或生存.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点抑制剂 (ICI) 已经改变了癌症治疗.
- 心血管 (CV) 事件是ICI的潜在副作用.
- 治疗前减少的左心室喷射率 (LVEF) 是已知的其他疗法心脏毒性风险因素,但其对ICI的影响不太清楚.
研究的目的:
- 评估ICI在癌症患者的安全性和有效性,这些癌症患者在治疗前的LVEF降低.
- 确定是否降低LVEF是接受ICI治疗的患者 CV不良事件或生存结果的独立预测因素.
主要方法:
- 对307名接受ICI治疗的患者进行了回顾性队列研究.
- 患者根据治疗前的LVEF评估 (正常与减少) 进行了分层.
- 主要安全终点:复合CV事件. 二次疗效终点:全因死亡率和无进展生存期 (PFS).
主要成果:
- 30名患者 (10%) 在治疗前减少了LVEF (平均39%±7%).
- 减少LVEF组的CV事件发生率较高 (37%对14%,p=0.004).
- 多变量分析表明,治疗前减少的LVEF不是CV事件 (p=0.358),全因死亡率或PFS的独立预测因素.
结论:
- 治疗前减少的LVEF不是接受ICI的患者不良临床结果的独立风险因素.
- 进一步的研究可能会完善心脏病患者ICI治疗的风险分层.
关键词:
心脏瘤学是一门专业.心脏有毒性 - 心脏有毒性国际投资机构 (ICI) 是国际投资机构 (ICI) 的一个组成部分.免疫检查点抑制剂 免疫检查点抑制剂免疫治疗是一种免疫疗法.在LVEF中,我们可以看到LVEF.更多相关视频
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