LDL-C/HDL-C比率与高尿血的关联:国家队列研究
Yanyu Zhang1, Xiaoyi Liu2, Deyun Luo2
1Clinical Laboratory, Panzhihua Central Hospital, Panzhihua, China.
较高的低密度脂蛋白胆固醇与高密度脂蛋白胆固醇 (LHR) 的比率与患上高尿路血症 (HUA) 的风险增加有关. 这一发现表明LHR可能是HUA风险评估的有价值预测指标.
科学领域:
- 代谢综合征是代谢综合征的一种.
- 心血管疾病风险因素 心血管疾病风险因素
- 生物标志物发现发现
背景情况:
- 超尿血症 (HUA) 是一种由清素代谢失调引起的代谢障碍.
- 确定HUA风险的可靠预测因素对于早期干预和管理至关重要.
研究的目的:
- 调查低密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率 (LHR) 对发展HUA的风险的预测值.
- 使用纵向数据评估LHR和HUA发病率之间的关联.
主要方法:
- 数据是从中国健康与退休纵向研究 (CHARLS) 数据库 (20112016) 中提取的.
- 使用多变量逻辑回归,受限立方线 (RCSs) 分析和线性相关性.
- 进行了子组分析和相互作用测试以完善研究结果.
主要成果:
- 较高的LHR与HUA发病率的增加显著相关 (p < 0.001).
- LHR与HUA风险独立相关 (OR = 1.27;95%CI = 1.161.39;p < 0.001).LHR与HUA风险独立相关 (OR = 1.27;95%CI = 1.161.39;p < 0.001).LHR与HUA风险独立相关 (OR = 1.27;95%CI = 1.161.39;p < 0.001).LHR与HUA风险独立相关 (OR = 1.27;95%CI = 1.161.39;p < 0.001).
- 限制立方线分析显示,LHR和HUA风险之间存在显著的非线性关联.
结论:
- 升高的LHR是增加HUA风险的重要预测因素.
- LHR可以作为HUA风险分层的有价值的生物标志物.
- 对LHR的进一步研究可能有助于HUA的预防和治疗策略.
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