统计方法用于调整对随机临床试验中干预遵守的影响,其中正在制定精确治疗规则
Nur Hani Zainal1, Corina Benjet2, Yesica Albor2
1Department of Psychology, National University of Singapore, Singapore, Singapore.
International journal of methods in psychiatric research
|January 9, 2025
概括
治疗效应 (HTEs) 的异质性可能源于遵守或有效性差异. 这项研究开发了一个预期的合规性得分,以在心理治疗试验中统计区分这些因素.
科学领域:
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
- 临床试验 临床试验
背景情况:
- 治疗效应 (HTEs) 的异质性可能来自于不同的治疗遵守或有效性.
- 区分这些来源对于精准医学至关重要,但在统计学上具有挑战性.
- 合规性通常在随机化后才被观察到,这复杂化了分析.
研究的目的:
- 在精密治疗分析中,在差异化治疗遵守性和有效性之间进行统计区分.
- 引入和验证一种在心理治疗试验中区分HTE来源的方法.
- 分析一项评估互联网认知行为疗法 (i-CBT) 试验的二次数据.
主要方法:
- 利用基线共变量来预测随机对导向i-CBT的参与者的合规性.
- 为两个干预组生成一个交叉验证的内部预期合规得分.
- 在扩展的HTE分析中将预期的合规得分作为预测指标.
主要成果:
- 对i-CBT的显著干预效应仅在具有高预期遵守率的参与者中观察到.
- 考虑到预期的合规性,剩余的HTE没有统计学意义.
- 这些发现表明,合规是观察到HTE的一个关键因素.
结论:
- 调查HTE的未来心理治疗试验应该经常纳入预期合规性复合分数.
- 这种方法可以更清楚地区分差异化待遇的遵守和有效性.
- 精确的区分对于推进精确心理治疗至关重要.
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