星球细胞的损失通过减少脂肪性同情性输出增加了体重
Dan Chen1, Yale Y Yang2, Yunlei Yang1,3,4,5
1Department of Medicine Division of Endocrinology, Albert Einstein College of Medicine, Bronx, New York, USA.
Glia
|January 9, 2025
概括
星球细胞通过调节体重来预防肥胖至关重要. 在下丘脑中失去星球细胞会增加体重,突出显示它们在能量恒温中的作用.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究研究 代谢研究
- 内分泌学 在内分泌学.
背景情况:
- 星球细胞在能量代谢和平衡中发挥作用.
- 天星细胞在体重调节中的具体作用尚不清楚.
研究的目的:
- 为了研究天体细胞在下丘脑 (ARH) 弧形核中的生理作用,以控制体重.
- 阐明星细胞调节人体体重的机制.
主要方法:
- 在成年小鼠中利用病毒载体辅助,大脑区域选择性丧失星球细胞.
- 用或高脂肪饮食来评估体重变化.
- 测量脂肪组织中的北上腺素 (NE) 含量.
- 采用脂肪组织交感输入的化学遗传刺激.
主要成果:
- 在ARH中选择性丧失星球细胞显著增加了和高脂肪饮食中的小鼠的体重.
- 星球细胞的损失导致脂肪组织中上腺素含量减少.
- 刺激交感神经系统输入脂肪组织,扭转了由天体细胞损失引起的体重增加.
结论:
- 星球细胞对于预防饮食引起的肥胖是必不可少的.
- 星球细胞通过影响对脂肪组织的交感外流来调节体重,从而影响脂质代谢.
相关概念视频
Sympathetic Activation
5.0K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
5.0K
Sympathetic Signaling
860
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
860
The Sympathetic Nervous System
94.4K
Overview
94.4K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
1.2K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.2K
Regulation of Food Intake
185
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
185
Neural Regulation of Blood Pressure
2.6K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.6K


