在人类CD4+T细胞中以表型为主导的IL-10上调剂的鉴定及其作为高度选择性的CDK8/CDK19抑制剂的药理学的阐明

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Simon Nicolle1, Mike Barker1, John Barrett2

  • 1Medicine Design, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Journal of medicinal chemistry
|January 9, 2025
PubMed
概括

研究人员确定了一种新型的pyrimidyl-piperidine化合物,该化合物可以增强interleukin-10 (IL-10) 产量,从而有可能治疗炎症性肠病 (IBD). 这种选择性CDK8/19抑制剂在临床前模型中显示出有效性.

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