自然免疫分子尿Tamm-Horsfall蛋白和素3作为复发性尿路感染严重性的预测因素:单中心自我控制研究
Zongping Li1, Yingru Xu2, Qian Wang1
1Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Renal failure
|January 9, 2025
概括
尿-马蛋白 (THP) 和Pentraxin 3 (PTX3) 作为预测复发性尿路感染 (RUTI) 严重程度和复发的生物标志物具有前景. 中国的草药配方Tailin Formula (TLF) 在改善RUTI结果方面表现出有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 天生的免疫失调有助于复发性尿路感染 (RUTI).
- 预测RUTI复发和识别容易患上白炎的患者仍然具有挑战性.
- 需要尿路生物标志物来评估RUTI的严重程度和治疗反应.
研究的目的:
- 评估尿液Tamm-Horsfall蛋白 (THP) 和Pentraxin 3 (PTX3) 作为RUTI症状严重程度和复发的预测因素.
- 评估中国草药配方泰林配方 (TLF) 在治疗RUTI中的疗效.
主要方法:
- 一项队列研究包括142名参与者:31人健康,111人患有RUTI.
- RUTI患者接受了持续低剂量抗生素治疗 (CLAT) 或TLF治疗.
- 在治疗前和治疗后测量尿液THP和PTX3水平.
主要成果:
- 尿液THP水平在RUTI患者中低于对照组;PTX3水平往往更高.
- 与CLAT相比,TLF治疗显著增加了尿液THP水平.
- 在治疗后,PTX3水平在CLAT和TLF两组都下降.
- THP与损伤标志物有负相关性,而PTX3与损伤标志物有正相关性.
- 改善的RUTI症状和减少的复发与增加的THP和减少的PTX3.3相关.
结论:
- 尿路THP和PTX3与RUTI病变发生有关.
- 这些生物标志物可以预测RUTI的严重程度,复发风险和治疗的有效性.
- TLF显示出作为RUTI治疗干预的潜力.
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