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难以治疗的类风湿性关节炎和可能的肉症之间的关联
Yoshifumi Ohashi1,2, Mochihito Suzuki3,4, Yasumori Sobue5
1Department of Orthopedic Surgery, Aichi Medical University, Graduate School of Medicine, Nagakute, Aichi 4801103, Japan.
Modern rheumatology
|January 9, 2025
概括
难以治疗的类风湿性关节炎 (D2T-RA) 与可能的麻症有关. 加强治疗控制可能有助于管理RA患者的皮病.
科学领域:
- 类风湿病学 类风湿病学
- 老年病的医生 老年病的医生
- 肌肉健康 肌肉健康
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症性疾病.
- 随着年龄的增长,肌肉质量和力量的丧失,即萨尔科佩尼亚,在慢性疾病中越来越令人担忧.
- 在RA患者中鉴定与肉类相关的因素对于及时干预至关重要.
研究的目的:
- 在被诊断患有类风湿性关节炎的患者中确定与可能的肉类相关的因素.
- 为了研究难以治疗的RA (D2T-RA) 和可能的肉症之间的关系.
主要方法:
- 使用SARC-F问卷 (得分≥4) 评估了可能的肉症.
- 患有D2T-RA的患者被定义为≥2个先前的生物/向性合成疾病修饰性抗风湿药物 (b/tsDMARD) 使用和中度至高的疾病活性.
- 多重逻辑回归分析在486名RA患者中确定了与可能的肉症相关的因素.
主要成果:
- 与可能的肉症相关的因素包括年龄较大,体重指数较高,D2T-RA,更大的残疾 (健康评估问卷-残疾指数) 和糖尿病.
- 与非D2T-RA患者相比,D2T-RA组的患病率明显更高,可能患有肉症 (60.5%vs17.4%) 和较低的甲状腺素使用率 (34.2%vs64.1%).
- 在D2T-RA队列中,大多数患者使用过两三种b/tsDMARDs.
结论:
- 难以治疗的RA是与可能的肉症相关的重要因素.
- 加强治疗策略和在RA中实现严格的疾病控制可能有助于预防或治疗.
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