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间歇性的负压会影响卧卧和坐着姿势期间的脊柱动脉剪切率

Nigel A Callender^1,2,3, Lars Øivind Høiseth^1,4, Iacob Mathiesen³

¹Faculty of Medicine, University of Oslo, Norway.

VASA. Zeitschrift fur Gefasskrankheiten

|January 9, 2025

概括

间歇性负压疗法增加了后动脉剪切率,特别是在卧卧的位置. 这种血管效应可能解释了下肢血管疾病的临床益处.

科学领域:

心血管生理学心血管生理学
血管生物力学血管生物力学
医疗工程是医学工程.

背景情况:

间歇性负压 (INP) 是一种新兴的治疗方法,用于下肢血管疾病.
它对大动脉血液动力学的精确生理影响尚不清楚.
了解INP对尾动脉剪切率的影响对于优化治疗至关重要.

研究的目的:

为了研究INP对尾动脉剪切率的影响.
为了比较这些效应,躺着与坐着的姿势.
阐明INP临床疗效的潜在机制.

主要方法:

十一个健康的参与者接受了INP应用到腿下部 (-37 mmHg).
使用双重超声波测量了民动脉的血流和剪切率.
血液动力学参数记录在躺着和坐着的位置.

主要成果:

卧卧姿势导致与坐姿相比,在基线和INP期间的平均剪切率显著更高.
INP在仰卧姿势中增加了平均剪切率,但在坐着姿势中显示出更细微的变化.
在这两种姿势中,振荡式剪切指数与基线发生了变化,表明剪切模式发生了变化.

结论:

INP会影响尾动脉剪切率,在卧卧姿势时效果更为明显.
观察到的剪切模式的波动可能有助于INP的积极临床结果.
需要进一步的研究来探索这些影响在患有血管疾病的患者.

关键词:

负压的压力是负的动脉剪切是动脉剪切.动脉样硬化动脉样硬化间歇性负压的间歇性负压.不侵入性治疗是一种非侵入性治疗.

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