人类表观遗传衰老时钟的跨组织比较
Abner T Apsley1,2, Qiaofeng Ye1, Avshalom Caspi3,4,5
1Department of Biobehavioral Health, Penn State University, University Park, Pennsylvania, USA.
Aging cell
|January 9, 2025
概括
在血液上训练的表观遗传钟可能会不准确地估计口腔组织中的生物年龄. 皮肤和血液时钟在血液和口腔样本中显示出最好的一致性,这表明特定于组织的时钟开发至关重要.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生物老龄化 生物老龄化
- 生物技术是生物技术.
背景情况:
- 表观遗传钟通过分析DNA甲基化模式来测量生物衰老.
- 目前的时钟主要是通过血液进行训练,限制了它们对其他组织的应用.
- 口腔组织 (口腔,唾液) 越来越多地被用于非侵入性衰老评估.
研究的目的:
- 评估表观遗传时钟在不同组织类型 (口腔与血液) 的可比性.
- 在将血源表观遗传钟应用于口腔组织时,以确定潜在的偏差.
- 为了评估皮肤和血液时钟在各种组织中的表现.
主要方法:
- 比较表观遗传年龄估计从口腔,唾液,干血斑点,毛和外围血液单核细胞.
- 分析了来自83名年龄在9至70岁的个体的284个样本.
- 对细胞比例和技术因素进行控制.
主要成果:
- 在口腔和血液组织之间发现了表观遗传年龄估计的显著差异,其中一些时钟差异约为30年.
- 基于血液的表观遗传时钟估计与基于口服的估计存在较低的相关性.
- 皮肤和血液时钟在所有测试的组织类型中显示出最高的一致性.
结论:
- 血源表观遗传时钟可能无法为口腔组织提供可比的年龄估计.
- 组织类型是表观遗传年龄估计的关键因素.
- 皮肤和血液的时钟显示了跨组织年龄评估的前景.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...