在急性冠状动脉综合征中缺铁:患病率和预后影响
Ana Fátima Esteves1, Sara Gonçalves1, Tatiana Duarte1
1Rua Camilo Castelo Branco, Cardiology Department, São Bernardo Hospital, Setúbal Hospital Centre, Setúbal, Portugal.
铁缺乏症 (ID) 在急性冠状动脉综合征 (ACS) 中很常见. 虽然ID没有预测ACS患者的死亡,但贫血显示出显著的影响,并且ID预测了死亡.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
- 血液学 血液学 血液学
背景情况:
- 缺铁 (ID) 是心力衰竭 (HF) 的已知预后标志物.
- 在急性冠状动脉综合征 (ACS) 中ID的影响尚未得到充分证实.
- 了解ID在ACS中的作用对于患者的治疗结果至关重要.
研究的目的:
- 评估与ACS入院的患者中ID的患病率和影响.
- 为了确定ID是否预测不良事件,如出血,红细胞输血,住院治疗或ACS患者的死亡.
- 为了比较具有和没有ID的ACS患者的特征和结果.
主要方法:
- 在2019年1月至12月期间接受ACS治疗的287名患者的回顾性分析.
- 患者被划分为具有或没有ID的组,并根据人口统计,住院细节,并发病症和心声学发现进行比较.
- 血液出血,红细胞输血,全因住院和全因死亡的ID预测值在28个月的中位随访期间进行了评估.
主要成果:
- 在48%的ACS患者中存在铁缺乏症.
- 与ST升高心肌梗塞患者相比,患有非ST升高心肌梗塞的患者更频繁地被诊断为ID.
- 在随访期间,ID患者的急诊室因心力衰竭 (HF) 的入院率显着更高,但ID并不能预测全因死亡. 贫血,年龄和NT-proBNP水平预测了所有死因的死亡.
结论:
- 在患有急性冠状动脉综合征的患者中,缺铁非常普遍.
- 贫血,而不是缺铁,似乎在急性ACS环境中对死亡率产生更大的影响.
- 需要进一步的研究来调查缺铁在ACS患者心力衰竭的发展中的作用.
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