胃食道逆流病与小肠细菌过度生长之间的相关性:肠道微生物组和代谢特征的分析
Zi-Teng Wang1,2, Wen-Tao Tan1, Jia-Li Huang1
1Gastroenterology Department, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.
胃食道逆流病 (GERD) 与小肠细菌过度生长 (SIBO) 有关,特别是甲阳性SIBO. 在患有GERD和SIBO的患者中,肠道微生物群和新陈代谢不同.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 胃食道逆流性疾病 (GERD) 和小肠细菌过度生长 (SIBO) 是常见的胃肠道疾病.
- GERD,SIBO,肠道微生物群和新陈代谢之间的相互作用需要进一步研究.
- 抑制酸性药物对GERD患者SIBO发展的影响尚未完全理解.
研究的目的:
- 检查GERD和SIBO之间的关系.
- 为了确定GERD患者SIBO的风险因素.
- 探索患有同时存在GERD和SIBO的患者肠道微生物群和代谢资料的变化.
主要方法:
- 对394名被诊断患有GERD和/或SIBO的患者进行了回顾性分析.
- 通过GERD-Q尺度和胃镜进行GERD诊断;通过气和甲呼吸试验进行SIBO诊断.
- 16S rRNA测序用于肠道微生物群分析和代谢概况.
主要成果:
- 在SIBO阳性患者中,GERD的发病率更高 (P = 0.007),与甲 (CH4) 呼吸测试的相关性更强 (P = 0.020).
- GERD被确定为SIBO的独立风险因素;短期,低剂量的抑制酸性药物没有显著影响.
- 在SIBO阳性GERD患者中,主要的肠道细菌包括Bacteroides uniformis和Bacteroides stercoris;代谢变化涉及与ABC载体相关的代谢物.
结论:
- 在GERD和SIBO之间存在着重要的联系,特别是甲占主导地位的SIBO.
- 肠道微生物群的组成,特别是 Bacteroides uniformis,在患有GERD和SIBO的患者中发生变化.
- 与ABC载体相关的代谢失调,在同时发生GERD和SIBO的患者中观察到.
更多相关视频
00:06Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
Published on: August 23, 2019
08:33Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
相关概念视频
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
What is Monogastric Digestion?
