埃拉戈利克斯在受控卵巢刺激期间抑制排卵的作用:一个回顾性队列研究
David Soliman1, Rita Naoom1, Mohamed Zaied1
1Department of Embryology, Newlife Fertility Centre, Mississauga, Ontario, Canada.
F&S reports
|January 9, 2025
概括
口服elagolix (E) 的体外受精结果与用于下垂体抑制的注射性ganirelix (G) 相似. 这种口服GnRH抗剂为控制的卵巢刺激周期提供了潜在的更为患者友好的方法.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 药理学 药理学是指药理学的学科.
背景情况:
- 在试管婴儿中,控制卵巢刺激 (COS) 需要有效地抑制 pituitary gonadotropin.
- 可注射性淋巴激素释放激素 (GnRH) 抗剂,如甘利利克斯 (G),是这种抑制的标准.
- 口服GnRH抗剂提供了一个潜在的更方便的替代品.
研究的目的:
- 为了比较口服elagolix (E) 与注射性ganirelix (G) 在COS期间对垂体抑制的疗效和结果.
- 评估两种GnRH抗剂协议之间的关键IVF治疗终点.
主要方法:
- 追溯队列研究,比较194名接受COS的不孕症患者.
- 患者接受了口服elagolix (E) 或注射性ganirelix (G) 用于垂体抑制.
- 主要结局包括生化妊娠,持续植入和周期取消率.
主要成果:
- 在elagolix和ganirelix组之间,周期取消率没有显著差异 (7.0%对4.9%).
- 对于冷胚胎移植,elagolix与ganirelix相比显示出更高的生化妊娠率 (74.5%vs55.9%),这是统计学上显著的差异.
- 在新鲜或冷胚胎移植的其他次要结果中没有观察到显著差异.
结论:
- 口服elagolix (E) 似乎是一个可行的替代方案注射甘里里克斯 (G) 在试管婴儿下垂体抑制.
- 埃拉戈利克斯可能为控制卵巢刺激提供一种更为患者友好的,潜在的成本效益较高的选择.
- 需要进一步的前性研究来证实这些发现.
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