来自L-lysine盐配方的EPA和DHA的优越生物可用性:一个随机的,三向交叉研究
Christiane Schön1, Antje Micka1, Vishnupriya Gourineni2
1BioTeSys GmbH, Esslingen, Germany.
Food & nutrition research
|January 9, 2025
概括
欧米茄-3脂肪酸 (EPA和DHA) 对健康至关重要. 一种新型的omega-3-lysine盐 (Lys-FFA) 显示了比标准乙烯 (EE) 和甘油三 (TG) 形式显著更高的生物可用性.
科学领域:
- 营养科学 营养科学
- 药理动力学 药理动力学
- 生物化学 生化学
背景情况:
- 欧米茄-3脂肪酸,乙酸 (EPA) 和酸 (DHA),是必需的多不和脂肪酸 (PUFA).
- 局限的内源性生产和饮食摄入需要补充以获得最佳的健康益处.
- 了解不同omega-3配方的生物可用性对于有效补充至关重要.
研究的目的:
- 为了比较EPA和DHA的药理动力学和生物可用性,从一个新的omega-3-lysine盐 (Lys-FFA) 配方中.
- 为了评估Lys-FFA与标准乙烯 (EE) 和甘油三 (TG) 欧米茄-3配方相比.
- 评估EPA和DHA在单次口服剂量后在健康人群中吸收的效率.
主要方法:
- 采用了一种随机的,三向交叉研究设计.
- 21名健康受试者参与了这项研究.
- 对不同的配方测量了包括生物可用性,Cmax和Tmax在内的药理动力学参数.
主要成果:
- 与EE配方相比,Lys-FFA配方的EPA和DHA生物可用性明显更高.
- Lys-FFA 显示了9.33 倍 (0-12 小时) 和8.09 倍 (0-24 小时) 的EPA+DHA联合生物可用性,比 EE.
- 与TG相比,Lys-FFA显示了1.57倍 (0-12小时) 和1.44倍 (0-24小时) 的EPA+DHA生物可用性,具有有利的Cmax和Tmax值.
结论:
- 与乙烯基 (EE) 和甘油三 (TG) 配方相比,Omega-3酸盐 (Lys-FFA) 为EPA和DHA提供了更好的生物可用性.
- 莱斯-FFA配方绕过了EE吸收所需的酶分裂的需要,从而增强了吸收.
- 由于其改善的生物可用性,Lys-FFA为omega-3补充剂提供了更有效的选择.
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