结肠直肠癌及其微环境:简要回顾
Nauryzbay M Imanbayev1, Arip K Koyshybaev1, Nurgul M Kereyeva1
1Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Medical journal of the Islamic Republic of Iran
|January 9, 2025
概括
本综述探讨了结直肠癌 (CRC) 病原性,重点关注遗传环境相互作用和瘤微环境. 整合这些因素的个性化疗法是改善患者治疗结果的关键.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 的发病过程复杂,受遗传环境相互作用和瘤微环境的影响.
- 了解这些因素对于改善临床决策和患者护理至关重要.
研究的目的:
- 通过检查遗传环境相互作用来探索结肠直肠癌 (CRC) 病原性.
- 分析瘤微环境在CRC发育和进展中的作用.
- 评估当前的治疗反应,并确定提高疗效的策略.
主要方法:
- 2019年至2024年间出版的文学作品的叙事综述.
- 在PubMed上使用与结直肠癌和瘤微环境相关的关键词进行系统的搜索.
- 根据PRISMA指南,包括14项非常相关的研究.
主要成果:
- 研究包括多种设计 (临床,RCT,队列,系统性审查),样本大小各异.
- 关键的遗传突变 (KRAS,BRAF) 和MMR能力影响CRC病原体.
- 免疫细胞,膜信号传递和各种治疗反应突出显示了治疗的复杂性.
结论:
- CRC是多因素的,复杂的瘤动态涉及遗传,环境和免疫因素.
- 整合这些要素的个性化疗法对于治疗疗效至关重要.
- 持续的研究对于优化CRC治疗和患者的治疗结果至关重要.
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