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放射治疗改善了患有远程转移性头部和部状细胞癌的患者的生存率:一项回顾性研究

Mengwen Wang^1,2, Baitian Zhao^1,2,3, Amin Huang^1,4

¹State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

Journal of Cancer

|January 9, 2025

概括

将放射治疗 (RT) 添加到化疗中,显著改善了转移性头支状细胞癌 (mHNSCC) 患者的存活率. 这种组合疗法提高了mHNSCC患者的整体存活率 (OS) 和疾病特异性存活率 (DSS).

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
头部和部癌症研究研究

背景情况:

放射治疗 (RT) 在远程转移的头角状细胞癌 (mHNSCC) 中的作用仍然不确定.
现有的研究缺乏全面的数据,比较mHNSCC患者的化疗加RT与单独化疗.

研究的目的:

与单独化疗相比,研究使用化疗加RT治疗的mHNSCC患者的生存结果.
评估将RT添加到化疗对整体生存期 (OS) 和疾病特异性生存期 (DSS) 的影响.

主要方法:

对两个队列的回顾性分析:SEER数据库 (N=885) 和孙中山大学癌症中心 (SYSUCC,N=60).
患者接受了化疗加RT或单独化疗.
主要结局:整体存活率 (OS);次要结局:疾病特异性存活率 (DSS).

主要成果:

在SEER队列中,RT添加改善了一年的OS (46.6%至56.0%) 和三年的OS (10.4%至25.1%).
RT显著增加了三年DSS (28.9%对14.0%) 和中位数OS (10至13个月).
在SYSUCC队列中,随着RT的增加,三年后的生存状况 (62.8%对21.0%) 和中位数的生存状况 (14至29个月) 改善.

结论:

将RT与化疗相结合,可显著改善mHNSCC患者的OS和DSS.
应将RT视为化学疗法的有益补充,用于管理远程转移性头癌.

关键词:

在 SEER 计划中,远端转移的发生.辐射治疗疗法辐射治疗疗法头部和部的状细胞癌.幸存率幸存率生存率

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