在鼻粘膜黑色素瘤中免疫疗法治疗的结果
Rijul S Kshirsagar1, Jacob G Eide2, Jacob Harris3
1Department of Otolaryngology-Head and Neck Surgery, Kaiser Permanente Redwood City Medical Center, Redwood City, California.
American journal of rhinology & allergy
|January 9, 2025
概括
免疫疗法在约一半的鼻粘膜黑色素瘤患者中显示出局部反应,但很少改善转移性疾病. 需要进一步的研究来优化治疗时间和识别反应预测因素.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 黑色素瘤研究 黑色素瘤研究
背景情况:
- 鼻粘膜黑色素瘤 (SNMM) 与糟糕的生存结果有关.
- 与皮肤黑色素瘤相比,对SNMM的免疫疗法 (IT) 疗效的数据有限.
研究的目的:
- 为了评估被诊断患有鼻腔粘膜黑色素瘤的患者的免疫治疗结果.
- 定义IT在SNMM多模式处理中的作用.
主要方法:
- 在2000年至2022年期间,对52名因SNMM而接受IT治疗的患者进行了回顾性队列研究.
- 收集的数据包括患者人口统计,治疗方案和生存结果.
主要成果:
- 最常见的治疗包括手术,放射和IT (50%).
- 尼沃卢马布/伊皮利穆马布 (32.7%) 和潘布罗利祖马布 (26.9%) 是常见的治疗方案.
- 1,2,5年的总生存率分别为86.9%,74.1%和39.1%.
- 在44.2%的患者中报告了并发症.
结论:
- 免疫疗法可以在约50%的SNMM患者中实现局部反应.
- 在IT后转移性疾病的改善并不常见.
- 未来的研究将集中在最佳IT时间和预测响应标记上.
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