产前诊断的非综合性头骨突发症:一个范围审查
Gwendolyn E Daly1, Alexa Stefanko1, Catherine Henning1
1Division of Plastic and Reconstructive Surgery, Oregon Health & Science University, Portland, OR, USA.
概括
产前诊断的骨突症变得越来越可行. 本综述审查了关于在出生前诊断非综合征性关节缩症的文献,突出了改善患者护理的方法和潜力.
科学领域:
- 医疗成像医学成像
- 胎儿医学 胎儿医学
- 儿科手术 儿科手术
背景情况:
- 头骨突症是头骨早期融合的疾病,很少在产前诊断出来.
- 早期诊断可以显著改善患者的治疗结果,并简化护理途径.
- 医疗技术的进步正在增加产前检测的可行性.
研究的目的:
- 系统地审查现有的关于非综合征性骨突症的产前诊断的文献.
- 确定目前在产前成像研究中使用的诊断标准和方法.
主要方法:
- 在Embase,Cochrane和PubMed中使用PRISMA指南进行了全面的文献搜索.
- 专注于综合征性关突症的研究被排除在分析之外.
- 包含的文章讨论了使用各种成像技术进行非综合征性骨突症的产前诊断.
主要成果:
- 文献搜索产生了2129篇文章,其中12篇符合最终分析的纳入标准.
- 在12项研究中,有10项 (83.3%) 使用胎儿生物识别数据 (例如双双体直径,头骨指数) 来评估胎儿头部形状.
- 两项研究 (16.7%) 使用了特定的超声波标记,如"大脑影像标志",一项研究引入了对斜突的定量查方法.
- 在所有包括的研究中,在怀孕的第二或第三个三个月内可以实现产前诊断.
结论:
- 在产前诊断非综合征性关节缩症是明显可行的现有技术.
- 建立标准化查协议和超声波诊断指标对于推进骨突症护理至关重要.
- 改善产前检测具有优化患者治疗结果和护理管理的巨大潜力.
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