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相关概念视频

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

1.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
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Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K

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相关实验视频

Updated: Jun 3, 2025

Histological Quantification of Chronic Myocardial Infarct in Rats
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Histological Quantification of Chronic Myocardial Infarct in Rats

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左心室射出小部分的预测者在患有ST段升高的心肌梗塞的患者中减少

K G Pereverzeva1, S S Yakushin1, I E Tishkina2

  • 1Pavlov Ryazan State Medical University.

Kardiologiia
|January 9, 2025
PubMed
概括

在ST段升高心肌梗塞 (STEMI) 患者中,可以预测左心室喷射率 (LVEF). 心力衰竭史,急性心力衰竭,LV扩张和高NT-proBNP预测较低的LVEF.

科学领域:

  • 心脏病学 心脏病学
  • 生物医学工程 生物医学工程
  • 临床研究 临床研究

背景情况:

  • ST段升高心肌梗塞 (STEMI) 可能导致左心室 (LV) 功能受损.
  • 预测LV射出分数 (LVEF) 对于管理STEMI患者至关重要.
  • 准确的预测模型可以指导治疗策略并改善患者的治疗结果.

研究的目的:

  • 在STEMI患者中确定LVEF的关键预测因子.
  • 在这个人群中开发和验证LVEF的预测模型.
  • 根据LVEF对STEMI患者进行分层,以根据风险量身定制的管理.

主要方法:

  • 对138名在24小时内入院的STEMI患者进行前性注册表研究.
  • 在第一天进行生物标记分析 (NT-proBNP,PCSK9,hs-cTnI,CRP).
  • 序列回声心脏图 (第1天和第10-12天) 用于计算LVEF.
  • 顺序回归分析以确定预测因素并构建预后模型.

主要成果:

  • 较低LVEF的预测因素包括慢性心力衰竭史,基利普II-IV级急性心力衰竭,LV扩张,心脏病发作后动脉瘤和NT-proBNP升高.
  • 开发的模型对预测降低的LVEF (94.4%) 和中度降低的LVEF (92.9%) 显示出高灵敏度.

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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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Histological Quantification of Chronic Myocardial Infarct in Rats
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Histological Quantification of Chronic Myocardial Infarct in Rats

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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

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  • 预测保存LVEF的模型灵敏度为62.5%.

    • 结论:

    • 史前患有慢性心力衰竭,急性心力衰竭 (Killip II-IV),LV扩张,心脏病发作后动脉瘤和NT-proBNP升高的STEMI患者可能会减少LVEF.
    • 已建立的模型有助于识别风险受损 LV 功能的 STEMI 患者.
    • 早期识别可能减少LVEF的患者,可以促进及时干预.