相关实验视频

Updated: Jun 3, 2025

In Vivo Surface Electrocardiography for Adult Zebrafish
09:13

In Vivo Surface Electrocardiography for Adult Zebrafish

Published on: August 1, 2019

14.1K

对于QT评估的暴露建议是否得到满足?

Tsubasa Wakabayashi1,2, Mamoru Narukawa1

  • 1Department of Clinical Medicine (Pharmaceutical Medicine), Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.

Journal of clinical pharmacology
|January 9, 2025
PubMed
概括

许多药物在早期研究中未能达到高临床暴露 (HCE),这可能会延迟开发. 优化早期研究设计以实现双重治疗暴露对于满足监管要求和避免 QT 途径研究失败至关重要.

关键词:
在 ICH E14 中.延长QTc的时间风险投资额外的风险保证金.高临床暴露的临床暴露.综合风险评估 综合风险评估

更多相关视频

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

8.6K
Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish06:15

Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish

Published on: August 16, 2024

375

相关概念视频

Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
294
Electrocardiogram01:29

Electrocardiogram

An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
2.2K
Exercise Stress Test01:26

Exercise Stress Test

Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
166