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Updated: Jun 3, 2025

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利用硫换氧转变:一种魔法子弹,用于印度尔-巴比图里酸结构的动态光物理和抗癌活动

Kartikay Tyagi1, Reena Kumari1, V Venkatesh1

  • 1Laboratory of Chemical Biology and Medicinal Chemistry, Department of Chemistry, Indian Institute of Technology Roorkee, Uttarakhand, 247667, India.

ChemMedChem
|January 9, 2025
PubMed
概括

研究人员开发了一种使用硫替代氧的单原子替代方法,以创建新的N-乙烯-乙烯-乙烯酸化合物. 这些分子显示出改善的光物理性质和强大的抗癌活性,其中化合物6a显示出显著的疗效.

关键词:
聚合引发的排放量 聚合引发的排放量线粒体膜潜在的潜力一个单个原子的替代.结构性的活动关系.

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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