新型精神活性物质检测分析方法的进步:一篇综述
Alex J Krotulski1,2, Dani C Mata3,2, Christina R Smith4
1Center for Forensic Science Research and Education, Fredric Rieders Family Foundation, Horsham, PA, United States.
Journal of analytical toxicology
|January 9, 2025
概括
在法医毒理学中分析新型精神活性物质 (NPS) 是一个挑战. 先进的分析仪器,特别是高分辨率质谱 (MS),改善了NPS检测和量化,尽管免疫测试仍然对某些药物类有用.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 新型精神活性物质 (NPS) 在法医毒理学中存在重大分析挑战,原因是它们的快速出现,短检测窗口和可变的强度.
- 准确识别,检测和量化NPS及其代谢物对于公共卫生和法律诉讼至关重要.
研究的目的:
- 审查和比较用于NPS分析的各种分析工具的优缺点.
- 为法医实验室提供参考,以根据其能力选择适当的技术.
主要方法:
- 2010年至2023年间发表的200多篇文章的综合文献综述,最终分析包括180篇文章.
- 根据使用的分析技术对审查的文章进行分类:免疫试验,气色谱-质谱 (GC-MS),液色谱-低分辨率MS (LC-MS-LR) 和液色谱-高分辨率MS (LC-MS-HR).
- 将数据组织成表格,详细说明作者,NPS药物类别和仪器仪表,以便方便查阅.
主要成果:
- 分析仪器的进步,特别是高分辨率质谱 (HRMS),已经显著提高了分析NPS的能力.
- 传统的免疫检测仍然是特定NPS类的有价值的查工具,例如二.
- 该综述提供了分析技术的分类概述,帮助实验室选择方法.
结论:
- 高分辨率质谱是克服NPS分析障碍的关键技术,提供更好的灵敏度和特异性.
- 技术的组合,包括免疫测试和各种形式的染色学与MS相结合,为NPS检测提供了一个强大的方法.
- 这篇评论是法医毒理学家在NPS分析的复杂性方面进行导航的宝贵资源.
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